Medicinal Chemistry
CHEM-4523

David Norman, Department of Chemistry, U.N.B.
Winter 2009

Calendar Description | Instructor | Timetable | Prerequisites | Textbook | Blackboard | Examinations | Grading | Course Topics | Plagiarism

Calendar Description:

3 ch (3C) Description: An introduction to medicinal chemistry. Topics include drug discovery, design, and development, QSAR, combinatorial synthesis, computational medicinal chemistry, and other selected topics. Relevant aspects of protein and nucleic acid chemistry may also be covered.

Instructor:

David Norman
Office: Toole 226
e-mail: david.norman@unb.ca

Timetable:

January 7 - April 8, 2009

Lectures: M,W,F: 12:30-1:20, Toole 303

Pre/Corequisites:

• Prerequisite: BIOL 2033/2043.
• Corequisite: CHEM 3421 or CHEM 3422.

Textbook:

Required textbook:

Graham L. Patrick, "An introduction to Medicinal Chemistry", 3rd Ed., Oxford University Press, 2005. Available at UNB Bookstore.

Supplementary references:

• G. Thomas, "Medicinal Chemistry. An Introduction", 2nd Ed. Wiley, 2000.
• R. B. Silverman, "The Organic Chemistry of Enzyme-Catalyzed Reactions", 2nd Ed. Academic Press, 2002.
• C. Branden & J. Tooze, "Introduction to Protein Structure", 2nd ed., Garland, 1998.
• L. Stryer, "Biochemistry", 4th/5th ed., Freeman, 1995/2002.

Web:

Course website (public) : http://taxane.chem.unb.ca/GD/courses/3523/3523.html

Course website (Blackboard): Courseware developed for CHEM 4523 will be available through the Blackboard course management system. Point your browser to http://learning.unb.ca and use your UNB PIN to login.

Examinations:

Grading:

Course Topics (tentative listing):

• Drug discovery, design, and development
• QSAR
• Peptide synthesis / Combinatorial synthesis
• Computational medicinal chemistry
• Principles of enzyme catalysis
• Enzymes and receptors as drug targets
• Peptidomimetics
• Nucleic acids as drug targets
• Special Topics
  

Plagiarism:

The University of New Brunswick places a high value on academic integrity and has a policy on plagiarism, cheating and other academic offences.

Plagiarism includes:
1. quoting verbatim or almost verbatim from any source, including all electronic sources, without acknowledgement;
2. adopting someone else’s line of thought, argument, arrangement, or supporting evidence without acknowledgement;
3. submitting someone else’s work, in whatever form without acknowledgement;
4. knowingly representing as one’s own work any idea of another.

Examples of other academic offences include: cheating on exams, tests, assignments or reports; impersonating somebody at a test or exam; obtaining an exam, test or other course materials through theft, collusion, purchase or other improper manner, submitting course work that is identical or substantially similar to work that has been submitted fro another course; and more as set out in the academic regulations found in the Undergraduate Calendar.

Penalties for plagiarism and other academic offences range from a minimum of F (zero) in the assignment, exam or test to a maximum of suspension or expulsion from the University, plus a notation of the academic offence on the student’s transcript.

For more information, please see the Undergraduate Calendar, Section B, Regulation VII.A, or visit http://nocheating.unb.ca. It is the student’s responsibility to know the regulations.